The chapter inquires into the question of whether studying regionalism in post-Soviet Eurasia can contribute to the comparative regionalism debate. It departs from discussing the treatment of Russia and post-Soviet Eurasia within the multiple modernities paradigm and, based on that, identifies an ambiguity in how European regionalism is perceived: as a sui generis phenomenon specific to the region and replicating the old power structures of the Soviet and Tsarist eras or as yet another example of regionalism, which can be subjected to investigation within the comparative regionalism model. The chapter then looks at three research questions, which are relevant for comparative study of regions and where European regionalism could constitute an interesting empirical setting: the role of the EU as a “blueprint” for regional organizations; autocracy promotion by non-democratic regional organizations; and the status of being an actor in regional organizations in non-democratic settings. It concludes that Eurasian regionalism, while clearly not a “typical” case, still can be studied to identify interesting and important phenomena relevant for the overall comparative regionalism agenda.