In this chapter, research findings on stressors occurring during adolescence and their effects on health status are presented. A variety of salient stressors that the adolescent is most likely to be confronted with is described, and it is discussed how the accumulation of such stressors may exert negative effects on the adolescent's physical and psychological health. In addition, the question of whether adolescents today are subjected to more stress than in the past is addressed. The chapter begins with findings about the frequency of body complaints in adolescence, and makes apparent that a lack of illness does not necessarily imply well-being.