Presenting a taxonomy of multiple approaches, this chapter presents an explanatory framework to evaluate individual approaches in design. Making sense of different designers and their skill affiliations/epistemologies, it describes the application of multiple skills in the context of the domain-individual-field interaction model, the reciprocal priority of skill usage, and the conceptual blending of skills. The metaphor of ensemble is used to understand how multiple skills can be recombined in meaningful ways and allow for unique/creative design products. The chapter concludes by outlining the implications of multiple skills to practice, teach, and research.