“Know thyself,” is an ancient aphorism that can inspire different perspectives to tackle the sustainability challenge. A challenge composed of many interdependent ones such as climate change, biodiversity loss, environmental degradation, geopolitical instability, refugees, poverty, and social inequality. It is a unique moment in the history of humankind, and because of the likely influence of humans on the planet’s natural systems, this epoch was named as Anthropocene. Of course, there is no certainty about the amount of human influence on the planet. These are complex processes, not direct cause and effect, and scientific thinking is limited. It cannot be certain of everything. However, despite its limitation, there is a huge faith in technology. There is a hope that science will fast develop new technologies that will save the planet and humanity. The problem is that the same technology that can tackle the sustainability challenge can contribute to make it even worst. It all depends on the assumptions used to develop and to use that technology. The danger is that technology is moving faster than the human understanding about oneself and reality.