This chapter explores ways of overcoming deeply entrenched falsehoods about albinism and the enlightenment of all stakeholders, including persons with albinism and caregivers. It focuses mainly on the role of education and research as the most fundamental long-term approach in achieving these goals. In doing this, it begins by developing a blueprint for a reconstructive and awareness education and training exercise for key social institutions in African societies. This is followed by a discussion of how a reconstructive and awareness exercise is also essential for persons with albinism. It then proceeds to identify important social structures that must be put in place to improve the quality of care for persons with albinism and minimise the burden of care for primary caregivers such as family members. Lastly, the chapter examines the prospects and implications of recent advancement and research in gene therapy could have for albinism and persons with albinism in African societies today.