This chapter focuses on providing answers to the question: How do accepted norms of action in African communities affect the well-being of persons with albinism? To answer this, the chapter begins by exploring an African moral theory, that is, the fundamental moral principle of human action in African thought. It then proceeds to explore and critique a ground for the moral justification of the discrimination against persons with albinism in African communities. This is followed by an analysis of other essential issues concerning the ill-treatment of persons with albinism, such as the question of moral responsibility toward those considered an other in African context, the challenges of caring for a disabled person and the problems associated with an inherent elite-virtue ethic in African traditions.