This chapter explores the epistemic injustice that has been done to persons with albinism in African societies through deeply entrenched theories of knowledge and processes of knowing in African thought. It begins with an attempt to construct an African theory of knowledge by theorizing three interrelated levels on which an African can claim to know anything: (i.) knowledge understood as first-hand information; (ii.) knowing consistency with established beliefs; and (iii.) knowledge as implying ‘we know that’. It then proceeds to 53an examination of the African processes of knowing or modes of knowledge acquisition. The chapter also examines factors responsible for the persistence of false and harmful beliefs about albinism in Africa today and the role epistemic ignorance play in this process.