This chapter explores albinism as a thick concept with both descriptive and normative dimensions. It begins by examining the descriptive, biological or scientific dimensions of the conception of albinism, a human genetic disorder resulting in partial or complete lack of pigmentation. It also discusses the concept of albinism as a form of disability. It then explores the normative conceptions of albinism in Africa, which is replete with ideas that cause intense physical and psychological harm to persons with albinism. The chapter concludes by examining two peculiar situations faced by persons with albinism in African societies. The environmental situation and the glaring difference situation of being white in a densely black community.