In this chapter, we see the Humachine emerging in front of our eyes. Human-centric orientation, flat & fluid organizational structures, entrepreneurial and innovative cultures, and enterprise-level self-awareness define the Humachine and distinguish it from traditional business structures. We explain the necessity of purposeful, mission-driven disruption to organizational structure in order to create a cultural and technological ecosystem that supports mutation. We introduce the concepts of rendanheyi and holacracy as examples of flat and fluid organizational structures. The three variables of Kasparov’s Law—people, machine, and process—need to be unified around the intentionality of the enterprise. The Humachine is capable of delivering products and services that excel in the experiential economy because they are co-created by humans and machines, workers and consumers. Drawing intelligence through its porous organizational boundaries, the Humachine delivers innovation rapidly to market. Ultimately possessing self-awareness at the enterprise level, the Humachine is not business transformed, it is business mutated, dynamically adapting to evolutionary pressures.