Findings from a range of clinical outcome studies indicate that cognitive behavioral therapy (CBT) paired with pharmacotherapy will be helpful for most adults seeking treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). However, clinical practice with “free-range” humans abounds with complicating factors that may get in the way of achieving optimal outcomes. In fact, the same core symptoms and executive dysfunction and motivation deficits characteristic of ADHD interfere with the effectiveness and delivery of treatment, from keeping up with prescription refills to implementing psychosocial coping strategies, not to mention simply attending scheduled appointments.