An iatrogenic disorder is any adverse condition that occurs as a result of a diagnostic procedure or therapeutic intervention that is not the natural consequence of the underlying disease. The most common iatrogenic events in neonates include nosocomial infections, catheter-related complications, unplanned extubations and intubation injury. To minimize the risk of nosocomial infections, good infection control and effective hand-washing policies are essential. Medication errors occur all too frequently in busy neonatal units (NNUs), but these can be minimized by safe drug prescribing and administration practices and the inclusion of an experienced neonatal clinical pharmacist in daily ward rounds to check drug and total parenteral nutrition prescription charts and to give advice about safe drug use. Other advances increasingly being used include electronic prescribing, smart infusion pumps and the use of standardized drug infusion concentrations.