This book was written with the intention of providing a comprehensive and up-to-date review of the clinical and biochemical significance of zinc. Within that framework, the two objectives were (1) to emphasize the common etiological aspects of clinical abnormalities of zinc metabolism and (2) to constructively examine the interactions of zinc with essential nutrients. Some of the major reviews on the clinical aspects of zinc metabolism have dealt very well with the etiological aspects of zinc depletion, but the clinical and biochemical implications of the interactions of zinc with nutrients other than proteins have not previously been adequately reviewed.