The effects of dietary components on metabolic and physiological processes are known to be significantly influenced by the presence or absence of other nutrients. There is evidence that fructose participates in many of these dietary interactions. If, as indicated by the material presented in Chapter 7, fructose is responsible for the major lipogenic effects of sucrose, then an interaction between saturated fat and fructose exists that produces larger increases in blood triglycerides of humans than does the combination of fructose and polyunsaturated fat. 14 In this chapter the interactions of dietary fructose with mineral status and bioavailability (especially that of copper), amino acid absorption, and ethanol metabolism will be described, possible mechanisms of action explored, and the significance to health and well-being discussed.