Carotid endarterectomy in the hands of experienced operators remains the best option for treating carotid artery disease under most circumstances. Considering the advanced age and medical comorbidities of vasculopath patients, clinical attention is now more focused on the less invasive percutaneous interventions as a safer alternative to open surgery. Simultaneous advances in endovascular techniques have made endovascular interventions in different vascular beds (cervical, carotid, renal, visceral, aortic and Iliofemoral arteries) possible, to the extent that the endovascular approach is now considered as first-line management for both coronary and non-coronary atherosclerotic disease, as it carries less cardiovascular morbidity and mortality in high-risk surgical patients. This chapter discusses the available evidence, indications and technical aspects of the carotid artery stenting procedure that is now commonly performed by both vascular surgeons and interventional cardiologists.