ABSTRACT

Insulin resistance in metabolic syndrome results, at least, from the overconsumption of dietary carbohydrates, cholesterol, and triglycerides leading to the formation of visceral adiposity, increased plasma-free fatty acids, and secretion of pro-inflammatory cytokines, which at cellular level decrease insulin receptor functionality also known as insulin resistance. 1,2 Once insulin resistance is established, increased postprandial glycemia, according to genetic susceptibility, introduces the development of type 2 diabetes and cardiovascular insults. 3–6 Thus, inhibiting the absorption of dietary carbohydrates and fats (cholesterol and triglycerides) with natural products or extracts of medicinal plants constitutes one therapeutic strategy to prevent or manage insulin resistance in metabolic syndrome.