The computer mouse, smart screen, and joystick are some of the mechanical devices that are used by most people to control a computer or other similar devices. However, a significant number of people with disabilities or due to weaknesses, or who are in special circumstances are unable to use such devices. A number of mechanical-based interfaces are now available that facilitate such users to control machines and computers. One example is the smart glove, which is a technology that has embedded mechanical sensors that can identify the intended command of the user. This chapter describes these technologies, and discusses the different options, applications, and the limitations.