This chapter provides an overview and rationale for research being undertaken in the area of human-computer interface design, in the context of non-idiomatic or free improvisation. The aim of this chapter is to bring together three areas of enquiry: cognitive-cultural networks, ecosystemic design and brain-computer interfaces, with the purpose of exploring their potential application within the realm of musical improvisation and to provide a rationale for future creative developments in this area. The theoretical themes of the chapter will be developed as a model for the creation of performance architectures and environments. As an exemplar, the recently created piece Mondrisonic will be described as an implementation of this model.