Originally considered pathognomonic to diagnostic entities such as schizophrenia and schizoaffective disorders, psychotic symptoms are in fact encountered in many other population groups, including those with neurological and general medical diseases as well as individuals who don’t seek clinical care. Psychotic symptoms may not be as unspecifi c as fever or headache in terms of their etiology, but are widely encountered in medicine. Hence, it is important for medical practitioners to be familiar with the specifi cities of presentation of psychosis in medical conditions and with the assessment and management of psychosis in these cases.