ABSTRACT This repeated-measures study investigated effects of the Transcendental Meditation1 technique on physiological and psychological variables in 17 prison inmates. Mter practicing the technique for 2 months, inmates showed increased stability of the autonomic nervous system, as indicated by fewer spontaneous skin resistance responses (SSRR), p < .001. They also showed reductions in rigidity, obsessive thoughts, and compulsive behavior, as indicated by two scales on the Minnesota Multiphasic Personality Inventory (MMPI), decreased Psychasthenia (MMPI scale 7, p < .025), and decreased Social Introversion (MMPI scale 10, p < .05).