This chapter explains the communication-centered approaches to organizational knowledge, by conducting a theoretical approach to organizational knowledge. It also clearly indicates that there is no one-size-fits-all approach to organizational knowledge processes that result in positive health and well-being outcomes. Structurating activity theory (SAT) is one theory that can be used to guide formative organizational knowledge research and the operationalization of constructs into organizational practices. Previous SAT-based work used the theory to examine policy knowledge processes across organizational systems and also between professional and family systems. This work can easily be applied to other organizational contexts and to investigating connections between organizational knowledge processes and other health-related outcomes for various stakeholders, including patients, patient families, and organizational members. In health professions, the phenomenon of knowledge transfer and exchange (KTE) has become an important research focus. Early approaches to knowledge sharing in health professions focused on knowledge transfer between researchers and health practitioners.