Drawing upon one case of an interdisciplinary research collaboration, this chapter explores two dimensions of problem-making: the social construction of problems and the notion of problem-making as analytical strategy. Discussion is focused on the relationship between the problems identified by researchers and those generated by non-specialist research collaborators and participants. It is argued that interdisciplinary collaboration can lead to contestations which are at the same time troubling and productive, and that such problem-making needs to be seen as simultaneously a social process and a method.