Research focused on Indigenous peoples and cultures is a capacious and emerging area. Indigenous research comes with a prescription to rethink the questions asked, the theories chosen and the methods deployed in more traditional fields. Indigenous worlds and Indigenous knowledges are ordered in terms of different epistemologies and ontologies compared to many other Western disciplines. This chapter explores a range of Indigenous methodologies and epistemologies, examining them in relation to both traditional disciplines, but also in terms of Paul Sillitoe’s (2007) idea of interdisciplinarity as a ‘reordering of knowledge’ (p. 152). From this perspective the chapter teases out some of the ongoing tensions between the taking up of Indigenous methodologies in research, and the unravelling, but also the reproduction of colonial practices in an interdisciplinary space.