The loss of habitat due to agricultural production and the current species extinction rate are alarming and have increasingly negative impacts on the natural world and on humans. However, the rapidly expanding human population requires a future increase in the human food supply or changes in diet. Food production and natural landscapes interact to create ecosystem services for humans but often result in ecosystem damage. This chapter explores ecologically beneficial planning and management approaches in commodity agriculture, peri-urban and urban zone agriculture, and conservation science that can reverse some of the historic ecological damage. Reimagined agricultural landscapes and ecosystem planning at the regional scale is necessary to resolve the tension between food systems and sustainable ecosystem functions.