Learning at work has become increasingly more complex. We connect foundational concepts and studies within the learning sciences with ideas from knowledge-intensive work. Knowledge-intensive work refers to processes that involve the systematic use of formalized knowledge in fields of expertise. Such knowledge is often inscribed in and mediated by advanced cultural tools. This form of work is of larger infrastructures of knowledge and networked configurations. This means that technology creates new contingencies between participants and tools in the workplace. When the interfaces between humans and technologies changes participants will experience new divisions of labor that will create new mediational processes between social and cognitive processes and new infrastructures and tools. Many fields of knowledge contribute to our understanding of workplaces and the development of skills and competences needed in the labor. We argue here that the learning sciences should be placed at the heart of such contributions.