This chapter discusses the necessity for landscape architecture interventions at the territorial and regional scale. The contemporary world is at a tipping point, one that is disturbingly divided and environmentally devastated. In light of the precarious contemporary political and environmental contexts, there is an urgent need and responsibility for the profession to address the world’s most pressing and fundamental issues and to marry social and political justice. Myriad issues linked to climate change, deforestation, energy, water, and food security require a crossing of disciplinary and scalar boundaries, out-of-the-box design thinking, and bold policies, plans, and projects. The chapter outlines six broad strategies that address habitat preservation, new spatial and programmatic reconfigurations of territory, resource management, and settlement morphologies. It is a call to arms for the profession of landscape architecture to act now—before it is simply too late.