An increasing number of studies have shown the importance of participative climate in order to manage growing demands in matters of change and workloads in contemporary organizations. By reflecting on the case of five major Japanese pharmaceutical companies undergoing recent mergers and/or acquisitions (M&A), the authors explore the association between the presence of participative climate on one hand, and health and work motivation on the other, in order to clarify how this work climate helps create healthy workplaces. The analysis helps build an improved understanding of the role and the repercussions of participative climate and provides implications for future research and practice.