In this chapter the mixed-methods sequential explanatory design for network research and its main features are discussed, illustrating how this approach has helped to address some of the most basic network questions in organization and management. The authors vividly show the methodologic journey of Robert Agranoff and his colleagues in the past twenty years and how network researchers can keep expanding their methodological strategies, combining qualitative analysis (like interview data and coding strategies to build theory) and quantitative analysis (like using survey research and network visualization to test and develop hypotheses) at different stages in the design. The chapter finally discusses how this journey culminates in a five-phase sequential mixed-methods multiple network study on collaborative management.