115The early modern era witnessed some radical changes in the understanding of urban architecture and public open spaces. The aim of this essay is to explore the ways in which sounds have shaped the city of Rome and, in turn, how sounds themselves were shaped by the city. But this double movement is not merely rhetorical. The space of the city is defined by people inhabiting and using it. Therefore we have also to take into account the importance of the senses in order to understand how the built environment can itself play an active role in city life. With this in mind, the streets play a prominent role. As the most prevalent and instrumental feature of the city’s urban landscape, they form the main structure that carries life through and across it.