A brief review of self-regulation is presented, in addition to current knowledge about the prevalence, classification, etiology, phenomenology, outcome and treatment of regulatory disorders. The role of the environment as external regulator or dysregulator is also described, in addition to the importance of assessing both internal (within the infant) and external (within the environment) aspects of regulation in infants who have clinical problems. The case of an 11-month-old infant with regulatory disorder is used to illustrate the role of the family environment on the perpetuation of regulatory disorders and the impact of regulatory disorders on the family. Future directions for research are discussed.