Given that nursing is a potentially high-stress occupation, the present study examines the effect of specific occupational stressors, coping strategies and type A behaviour on job satisfaction and mental well-being of 475 UK senior nurses. Several stressors were identified which had a negative impact on job satisfaction. However, only stress associated with the nurse manager’s workload was consistently found to be a predictor of mental health outcome measures. In addition, cognitive and behavioural coping techniques were noted.