It is crucial for organizations to build and maintain a culture of continuous innovation to be successful. Organizational culture is a set of values, beliefs, and ways of thinking shared by members of the organization (Schein, 2010). According to Gliddon (2006), “as innovations become more radical, management of organizational culture is key” (p. 20). Innovation leaders are able to foster and promote organizational cultures that spark creativity and risk-taking, motivate and reward employees to think out of the box, and channel ideas to increase stakeholder value (Ahmed, 1998). However, these characteristics are not easily replicated by those organizations most in need of developing a culture of continuous innovation. In this chapter, you will gain an understanding of how innovation leaders assess, clarify, and communicate an organization’s culture and values; how they design and implement a new organizational culture; and how they build new roles and responsibilities to support innovation.