Benign and malignant liver tumors in infants comprise 4%–5% of all neoplasms in the fetus and neonate, and are being detected perinatally with increasing frequency through ultrasound.1 , 2 The spectrum of these pathological masses in newborns and infants is different from that found in older children (see Table 93.1). With advances in the understanding of the biology of these tumors over the past decades, approach to their treatment has also evolved. While most hepatic tumors are metastatic rather than primary, this chapter aims to describe the current and evolving approaches to the management of the most common benign and malignant primary liver tumors occurring in newborns (see Figure 93.1).