ABSTRACT
Cancer in the newborn is relatively rare, comprising only about 2.5% of all childhood malignancies1; the majority of tumors in the newborn are benign lesions. Overall, neuroblastoma is the fourth most common cancer of childhood, accounting for about 8% of all malignancies diagnosed in children younger than 15 years of age. Neonatal neuroblastoma, defined as neuroblastoma diagnosed prenatally or within 30 days after birth, accounts for approximately 5% of all cases of neuroblastoma.2 However, neuroblastoma is second only to teratoma as the most commonly diagnosed tumor in the neonate and is, overall, the most common malignancy in the newborn, accounting for 30% of all cancers diagnosed in this age group. With the increasing use of perinatal imaging, the incidence of neonatal neuroblastoma is very likely to increase.
