Cysts and abscesses of the liver in the neonatal period are uncommon. Hepatic cysts presenting in infants are usually simple, unilocular cysts, with polycystic liver diseases presenting later in childhood or in adults. Most abscesses in infants are pyogenic, with parasitic infections occurring in older children or adults. Cross-sectional imaging studies (ultrasound, computed tomography [CT], magnetic resonance imaging) can typically make workup and localization relatively straightforward. Antenatal diagnosis of liver cysts is now more common with improving scanning technology. Treatment, however, still requires experience and judgment to prevent recurrences or complications.