The Brazilian intellectual Miguel Ozório de Almeida participated in several intellectual and scientific societies in Brazil and abroad. In the interwar period, Miguel Ozório de Almeida took part in the League of Nations’ international project of intellectual cooperation. In 1946, he participated of UNESCO’s creation and was one of the Brazilian candidates for the place of head of the natural sciences sector and for director-general of the organization. The main objective of this chapter is to follow Miguel Ozório de Almeida’s activity in the last years of IICI and in the early years of UNESCO to discuss how internationalist projects may raise debates on the asymmetries in the dynamics of international intellectual relations and on the role of the Latin American intellectuals in these networks since the interwar period.