Blockchain is considered as one of the most disruptive technologies, with an estimated growth from USD 1.2 billion in 2018 to USD 23.3 billion by 2023 worldwide. Blockchain has the potential to disrupt all business activities as much as the internet, social media, and mobile technologies did in the past. It enhances the creation of new business models, and forces organizations to work differently. The chapter aims to analyze the potentiality and the effects of blockchain on current and future business models from an intellectual capital perspective, by applying a Structured Literature Review (SRL) on the most recent scientific as well as professional production on the topic. The findings highlight how the design principles of blockchain technology can enhance the intellectual capital of an organization, as well as lead to a business model innovation.