This chapter examines the links between R&D collaborative networks in the ICT field, the regional technological context and the related innovative outputs, for the case of the European Union. First, we consider the links established in these networks to check for the existence of bridging regions, i.e., those which connect isolated groups of regions. Second, we explore the relationships between the regional level of network connectedness and its technological and economic context. Finally, we study the impact of network connectedness on regional technological innovation. We find that the FP7 program has generated complex and unequal collaborative networks, confirming the systematic regional disparities in innovation within the EU. Indeed, the best-connected regions show more advanced economic, innovative and digital development.