In this chapter the importance of collaborating and co-working with the multi-disciplinary team is stressed, as well as agreement on priorities, with pragmatism around necessary medical interventions. The management of common medical issues seen in ARFID is discussed, including constipation, micronutrient deficiency, growth delay, and low bone density. Where acute medical instability or chronic effects upon growth are identified, weight restoration should be a priority, with clear explanations for the family. The role of medications in ARFID is explored, with a summary of recent evidence for their efficacy and safety. The chapter also explores the risk for re-feeding syndrome in ARFID and how clinicians can work effectively to identify it.