Mixed methods research (MMR) is an exciting, but challenging, approach to research in adapted physical education (APE) contexts. In this chapter, we mainly describe the underlying paradigm assumptions about MMR in this area. It is our paradigm assumption that our field’s researchers should be aware of the philosophical issues that may have a direct impact on how MMR is conducted. Further, we provide a rationale for the use of MMR in APE contexts as well as a brief description of a few MMR studies that have been performed. Given the lack of MMR in APE, we also provide examples of disability-specific studies through the lens of adapted physical activity. While MMR designs have not been used to the full extent in the field, we hope that more APE researchers will attempt to conduct future MMR studies to further our research knowledge and utilize clinically useful findings immediately for people with disabilities in meaningful ways.