Although negative responses to treatment are rampant, they are infrequently recorded in the literature. Insofar as many of our seriously ill adolescents are at risk for chronic courses, especially in the schizophrenic group, we decided to report on the two cases that were well documented in our les. The report happens to come at a time when we have pharmacologic agents that do alter the course for some patients and we also know that psychosocial interventions (including various psychotherapies) may be adjunctive but alone are relatively useless, Mme. Sechehaye and Frieda Fromm-Reichman notwithstanding. Although many of us grew up in psychiatry reading such cases and were impressed and enlightened about how the mind of the schizophrenic works, these cases remain dubious in their continuing relevance to our contemporary search for relief and improved adaptation. Currently, the focus on pharmacological agents alone or in company of other psychological supports seems to be the most promising avenue.