High mobility group (HMG) proteins are a group of chromosomal nonhistone proteins which associate with the active (or expressed) genes in the eukaryotic cells. 1 3 They exist universally in the eukaryotic kingdom, from yeast to mammalian species. 4 6 HMG proteins are closely associated with the nucleosomes which are the basic structural units of chromosome. 7 , 8 The importance of HMG proteins in correlation with gene regulation has been postulated, yet their functional role in gene expression is still unknown. The amount of HMG protein increase is proportional with the proliferational state of the tissue. 9 , 10 The possibility of HMG protein serving as the initiation signal for chromosomal replication has been suggested. 10