ABSTRACT

It is well known that long-term food restriction begun in the young rodent will prolong life, delay the onset of a number of diseases, and retard several physiological aging processes. 1 4 However, the mechanism of the life-prolonging and anti-aging actions of food restriction is unknown. One theory suggests that food restriction slows the rate of aging because it reduces the secretion of a pituitary aging factor. 1 , 5