ABSTRACT
By the end of the year 1989, 15 different mutagenic heterocyclic amines were isolated from cooked food, heated proteins, and heated amino acids (see Table 1). They are potent mutagens as tested by the Ames Salmonella assay. Moreover, ten of these compounds have been reported to be carcinogenic in rodents. It is no wonder that these findings have aroused ever-increasing concern and interest from scientists, and the general public alike, in the presence of these chemical entities in the diet. Mutagenic Heterocyclic Amines: A Chronological Listing<xref ref-type="fn" rid="tablefn2_1_1_1"> <sup>a</sup> </xref>
Year of report
Abbreviated name of heterocyclic amine
Ref.
1977
Trp-P-1
Sugimura et al. 8
1977
Trp-P-2
Sugimura et al. 8
1977
Phe-P-1
Sugimura et al. 8
1978
AαC
Yoshida et al. 17
1978
MeAαC
Yoshida et al. 17
1978
Glu-P-1
Yamamoto et al. 19
1978
Glu-P-2
Yamamoto et al. 19
1980
IQ
Kasai et al. 20
1980
MelQ
Kasai et al. 21
1981
MelQx
Kasai et al. 22
1981
Orn-P-1
Yokota et al. 23
1984
7,8-DiMeIQx
Negishi et al. 24
1985
4,8-DiMeIQx
Negishi et al. 25
1986
PhIP
Felton et al. 26
1988
IQx
Becher et al. 27
This table is a modification of a table in Reference 12. See Chapter 2.2 for a full description of the compounds.
