Hunan province of China is famous in the world for its plenty of non-ferrous metal ore (tungsten, bismuth, realgar) deposit. In the past several decades, intensive mineral exploitation, ore extraction, and refining activities has caused a large amount of waste such as mining waste water, together with the dumping of mining and smelting waste (arsenic residue, arsenic ash) on the soil surface and subjected to erosion and weathering processes, greatly affected the surrounding area and causing long-term and severe impact on soil and water environment. Pollution of paddy fields by Arsenic caused a severe threat to human health in Hunan province, because rice is a staple food and could accumulates higher levels of As compared to other crops. In the present study, a novel Nano manganese oxide with higher reactivity and oxidation ability has been synthesized. Pot experiment combined with field application has been conducted to explorer the potential of α-MnO2 Nano manganese oxides for the remediation of As polluted paddy soil. Results turns out that the application of α-MnO2 Nano-flowers can effectively control the transportation and accumulation of arsenic from soil to rice.