The presence of arsenic (As), a potent carcinogen, in industrial wastewater poses a serious threat to plant, animal, and public health, especially in the transition and developing countries. Recent developments in the field of bioremediation have enhanced our understanding about the microbial biotechnology processes governing As uptake and detoxification on laboratory and pilot scale. In particular, the biofilm and consortia remediation will prove invaluable in the developments of new strategies to mitigate this threat at industrial scale also. The role of microbial remediation of As in industrial wastewater cannot be neglected due to its proven significance as a natural sweeper that can mitigate As in wastewater without production of solid/liquid waste and reduce it to low toxic level.