Nanoadsorbents have gained considerable attention for arsenic removal in groundwater among scientific communities from last decade. Nanotechnology based water treatment systems are logical choice in respect to resource and energy efficiency. The literature is widely replete in cases of development of different nanoadsorbents which are explored for arsenic removal. Among these, nanoscale zero-valent iron has been observed extensively employed both at laboratory and pilot scale studies due to its strong affinity, easy availability and environmental friendly nature. Its unstable nature limits the application at large scale efficiently. In present study, γ-Fe2O3 nanoparticles were evaluated for arsenic removal using Taguchi’s design of experimental methodology for real world water conditions by formulating artificial groundwater.