We have evaluated epigenetic changes in the arsenic exposed population at West Bengal, India. We observed that the arsenic exposed individuals had changes in the promoter methylation status of tumor suppressive and DNA repair genes. The downstream effectors mainly proteins were also altered in case of arsenic exposure. Global miRNA profiling showed several altered miRNAs in arsenic exposed samples. Of the above altered miRNAs, a significant number was associated with arsenic induced senescence and diseases like skin lesions, skin cancer, respiratory distress and peripheral neuropathy.