ABSTRACT
Pregnancy represents a distinct immunologic state; the fetus acts as an allograft to the mother, needing protection against potential rejection. 1 , 2 Humoral immunoreactivity does not change much during pregnancy, with the exception of lowered immunoglobulin G concentration at late phase, probably explained by placental transport. 3 Regarding cellular immunity, reduction, 4 , 5 elevation, 6 and no variation 7 in the number of different lymphocytic populations have been reported. The final effect of pregnancy on previously active autoimmune processes is controversial, 8 , 9 and multiple autoimmune disturbances may be manifested during pregnancy. 10
