ABSTRACT

Mild Traumatic Brain Injury (TBI) is caused by a blunt force or direct blow to the head or elsewhere in the body, with an impulsive transmission to the brain resulting in acceleration/deceleration, translational, rotational, and/or angular forces. Mild TBI triggers a complex pathophysiological cascade involving ionic and neurometabolic changes and microstructural axonal dysfunction, resulting in somatic symptoms, cognitive and sleep impairment, and behavioral changes.