This chapter introduces spirituality in primary care from the perspective of two primary care practitioners. It begins with a brief overview of some of the issues facing those working in primary care and the importance of holistic approaches to care. The current evidence concerning spirituality in primary care is then reviewed before focusing on how to operationalise spirituality in this setting. Chapter 4 provided the framework of availability and vulnerability which is particularly salient in primary care and should be reviewed by the reader as a useful framework for operationalising spirituality. A number of verbatim quotes taken from the interview transcripts from a study by Penny of ANP’s in primary care have been included to offer insights into the provision of spiritual care in this setting (1).